Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): replicate control
SUBMITTER: Atul Butte
PROVIDER: E-GEOD-21340 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Patti Mary Elizabeth ME Butte Atul J AJ Crunkhorn Sarah S Cusi Kenneth K Berria Rachele R Kashyap Sangeeta S Miyazaki Yoshinori Y Kohane Isaac I Costello Maura M Saccone Robert R Landaker Edwin J EJ Goldfine Allison B AB Mun Edward E DeFronzo Ralph R Finlayson Jean J Kahn C Ronald CR Mandarino Lawrence J LJ
Proceedings of the National Academy of Sciences of the United States of America 20030627 14
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, and accumulation of intramyocellular triglycerides have all been linked with insulin resistance, but no specific defect responsible for insulin resistance and DM has been identified in humans. To identify genes potenti ...[more]