Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Gene expression during SMC cord morphogenesis

ABSTRACT: SMCs must undergo specialzed patterning during blood vessel stabilization. We used microarray analysis to identify differentially expressed genes as smooth muscle cells were induced to assemble into a network of elongated cords. Two time points (Day 0 and Day 8) and three biological replicates for each, using Affymetrix HGU133A and HGU133B arrays for each sample.

ORGANISM(S): Homo sapiens

SUBMITTER: J. Geoffrey Pickering

PROVIDER: E-GEOD-21363 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells.

Frontini Matthew J MJ Nong Zengxuan Z Gros Robert R Drangova Maria M O'Neil Caroline C Rahman Mona N MN Akawi Oula O Yin Hao H Ellis Christopher G CG Pickering J Geoffrey JG

Nature biotechnology 20110417 5

The therapeutic potential of angiogenic growth factors has not been realized. This may be because formation of endothelial sprouts is not followed by their muscularization into vasoreactive arteries. Using microarray expression analysis, we discovered that fibroblast growth factor 9 (FGF9) was highly upregulated as human vascular smooth muscle cells (SMCs) assemble into layered cords. FGF9 was not angiogenic when mixed with tissue implants or delivered to the ischemic mouse hind limb, but instea ...[more]

PMID: 21499246

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Dataset Information

Gene expression during SMC cord morphogenesis

Publications

Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells.

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