Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Human medulloblastoma


ABSTRACT: Whole-genome screening of DNA-copy number changes by array-based or matrix comparative genomic hybridization (matrix-CGH). Tumor DNA was hybridized against a single standard reference DNA-pool of the opposite sex than the patient. Every experiment was performed as dye-swap.

ORGANISM(S): Homo sapiens

SUBMITTER: Frank Mendrzyk 

PROVIDER: E-GEOD-2139 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma.

Mendrzyk Frank F   Radlwimmer Bernhard B   Joos Stefan S   Kokocinski Felix F   Benner Axel A   Stange Daniel E DE   Neben Kai K   Fiegler Heike H   Carter Nigel P NP   Reifenberger Guido G   Korshunov Andrey A   Lichter Peter P  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051201 34


<h4>Purpose</h4>Medulloblastoma is the most common malignant brain tumor in children. Despite multimodal aggressive treatment, nearly half of the patients die as a result of this tumor. Identification of molecular markers for prognosis and development of novel pathogenesis-based therapies depends crucially on a better understanding of medulloblastoma pathomechanisms.<h4>Patients and methods</h4>We performed genome-wide analysis of DNA copy number imbalances in 47 medulloblastomas using comparati  ...[more]

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