Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Frank Mendrzyk
PROVIDER: E-GEOD-2139 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mendrzyk Frank F Radlwimmer Bernhard B Joos Stefan S Kokocinski Felix F Benner Axel A Stange Daniel E DE Neben Kai K Fiegler Heike H Carter Nigel P NP Reifenberger Guido G Korshunov Andrey A Lichter Peter P
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051201 34
<h4>Purpose</h4>Medulloblastoma is the most common malignant brain tumor in children. Despite multimodal aggressive treatment, nearly half of the patients die as a result of this tumor. Identification of molecular markers for prognosis and development of novel pathogenesis-based therapies depends crucially on a better understanding of medulloblastoma pathomechanisms.<h4>Patients and methods</h4>We performed genome-wide analysis of DNA copy number imbalances in 47 medulloblastomas using comparati ...[more]