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Stp1 and Stk1 regulated genes during S. aureus post-exponential phase growth

ABSTRACT: Genes that showed altered expression in Stk1 and Stp1 deficient Staphylococcus aureus Newman were identified. strain comparison, global regulation Deletion mutants were examined for alterations in gene expression.

ORGANISM(S): Staphylococcus aureus

SUBMITTER: Lakshmi Rajagopal

PROVIDER: E-GEOD-21426 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase.

Burnside Kellie K Lembo Annalisa A de Los Reyes Melissa M Iliuk Anton A Binhtran Nguyen-Thao NT Connelly James E JE Lin Wan-Jung WJ Schmidt Byron Z BZ Richardson Anthony R AR Fang Ferric C FC Tao Weiguo Andy WA Rajagopal Lakshmi L

PloS one 20100611 6

Exotoxins, including the hemolysins known as the alpha (alpha) and beta (beta) toxins, play an important role in the pathogenesis of Staphylococcus aureus infections. A random transposon library was screened for S. aureus mutants exhibiting altered hemolysin expression compared to wild type. Transposon insertions in 72 genes resulting in increased or decreased hemolysin expression were identified. Mutations inactivating a putative cyclic di-GMP synthetase and a serine/threonine phosphatase (Stp1 ...[more]

PMID: 20552019

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