Wide-ranging fucntions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis

ABSTRACT: The transcription factor E2F4 is a member of the E2F family of regulators which has critical roles in cell cycle control and differentiation. We investigated the genome-wide binding profile of E2F4 using a newly developed peak calling program based on a kernel density estimation and identified approximately 16 thousands E2F4 binding sites at a 1% FDR threshold, which potentially modulate 7,346 downstream target genes. Gene Ontology (GO) functional analysis of E2F4 target genes revealed several novel functions of E2F4 including I-kappaB kinase/NF-kappaB cascade, protein transport and targeting, protein folding, and sterol biosynthetic process. In addition to mRNA target genes, E2F4 also binds and regulates some miRNA targets such as let-7a, mir-17 and mir-22. Interestingly, we found that ab

ORGANISM(S): Homo sapiens

SUBMITTER: Vishy Iyer 

PROVIDER: E-GEOD-21489 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress