Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Array CGH with DNA extracted from Candida albicans strains 3153A and its derivative Sor55, which is monosomic for chromosome 5


ABSTRACT: Goal of this experiment was to confirm the proposed monosomy condition of chromsome 5 genes in the mutant Sor55 Different batches of total DNA were prepared from the parental strain 3153A and its derivative Sor55. Hybridization included different combinations of two independent batches of DNA from 3153A or Sor55, as well as one dye-swap. Parental/mutant ratio data was analyzed.

ORGANISM(S): Candida albicans

SUBMITTER: Elena Rustchenko 

PROVIDER: E-GEOD-21616 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Widespread occurrence of dosage compensation in Candida albicans.

Kravets Anatoliy A   Qin Hong H   Ahmad Ausaf A   Bethlendy Gabor G   Gao Qinshan Q   Rustchenko Elena E  

PloS one 20100611 6


The important human pathogen Candida albicans possesses an unusual form of gene regulation, in which the copy number of an entire specific chromosome or a large portion of a specific chromosome changes in response to a specific adverse environment, thus, insuring survival. In the absence of the adverse environment, the altered portion of the genome can be restored to its normal condition. One major question is how C. albicans copes with gene imbalance arising by transitory aneuploid states. Here  ...[more]

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