Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: frédéric leprêtre
PROVIDER: E-GEOD-21986 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Leukemia research 20100803 4
To ascertain genomic alterations associated with Imatinib resistance in chronic myeloid leukaemia, we performed high resolution genomic analysis of CD34(+) cells from 25 Imatinib (IM) resistant and 11 responders CML patients. Using patients' T-cells as reference, we found significant association between number of acquired cryptic copy number alterations (CNA) and disease phase (p=0.036) or loss of IM response for patients diagnosed in chronic phase (CP) (p=0.04). Recurrent cryptic losses were id ...[more]