Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Chaolin Zhang
PROVIDER: E-GEOD-22115 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhang Chaolin C Frias Maria A MA Mele Aldo A Ruggiu Matteo M Eom Taesun T Marney Christina B CB Wang Huidong H Licatalosi Donny D DD Fak John J JJ Darnell Robert B RB
Science (New York, N.Y.) 20100617 5990
The control of RNA alternative splicing is critical for generating biological diversity. Despite emerging genome-wide technologies to study RNA complexity, reliable and comprehensive RNA-regulatory networks have not been defined. Here, we used Bayesian networks to probabilistically model diverse data sets and predict the target networks of specific regulators. We applied this strategy to identify approximately 700 alternative splicing events directly regulated by the neuron-specific factor Nova ...[more]