Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Cecile Michel
PROVIDER: E-GEOD-2216 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Michel Cécile C Roberts Ruth A RA Desdouets Chantal C Isaacs Kevin R KR Boitier Eric E
Chemical research in toxicology 20050401 4
Evaluation of the nongenotoxic potential early during the development of a drug presents a major challenge. Recently, two genes were identified as potential molecular markers of rodent hepatic carcinogenesis: transforming growth factor-beta stimulated clone 22 (TSC-22) and NAD(P)H cytochrome P450 oxidoreductase (CYP-R) (1). They were identified after comparing the gene expression profiles obtained from the livers of Sprague-Dawley rats treated with different genotoxic and nongenotoxic compounds ...[more]