Unknown,Transcriptomics,Genomics,Proteomics

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Analysis of early primary breast cancer to identify prognostic markers and associated pathways: mRNA and miRNA profiling


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE22216: microRNA expression profiling of early primary breast cancer to identify prognostic markers and associated pathways GSE22219: Gene expression profiling of early primary breast cancer to identify prognostic markers and associated pathways Refer to individual Series. Supplementary file: Shows correspondence between mRNA and miRNA samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Francesca Buffa 

PROVIDER: E-GEOD-22220 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer.

Buffa Francesca M FM   Camps Carme C   Winchester Laura L   Snell Cameron E CE   Gee Harriet E HE   Sheldon Helen H   Taylor Marian M   Harris Adrian L AL   Ragoussis Jiannis J  

Cancer research 20110707 17


microRNA expression profiling plays an emerging role in cancer classification and identification of therapeutic strategies. In this study, we have evaluated the benefits of a joint microRNA-mRNA analysis in breast cancer. Matched mRNA and microRNA global expression profiling was conducted in a well-annotated cohort of 207 cases with complete 10-year follow-up. Penalized Cox regression including microRNA expression, mRNA expression, and clinical covariates was used to identify microRNAs associate  ...[more]

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