Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Benjamin Haibe-Kains
PROVIDER: E-GEOD-22250 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Dedeurwaerder Sarah S Desmedt Christine C Calonne Emilie E Singhal Sandeep K SK Haibe-Kains Benjamin B Defrance Matthieu M Michiels Stefan S Volkmar Michael M Deplus Rachel R Luciani Judith J Lallemand Françoise F Larsimont Denis D Toussaint Jérôme J Haussy Sandy S Rothé Françoise F Rouas Ghizlane G Metzger Otto O Majjaj Samira S Saini Kamal K Putmans Pascale P Hames Gérald G van Baren Nicolas N Coulie Pierre G PG Piccart Martine M Sotiriou Christos C Fuks François F
EMBO molecular medicine 20111116 12
Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimizing treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but the involvement of the epigenome in breast cancer and its contribution to the complexity of the disease are still poorly understood. By means of DNA methylation profiling of 248 breast tissues, we have highlighted the existence of previo ...[more]