Unknown,Transcriptomics,Genomics,Proteomics

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BRCA1 depletion effect on HeLa cells


ABSTRACT: Analysis of HeLa cells following depletion of BRCA1 tumor supressor using RNAi against BRCA1. Results provide insight into the molecular mechanisms underlying loss of the BRCA1 function. Six samples (three control samples and three BRCA1 depleted samples) have been analysed. For the control, the samples derived from the HeLa cells treated with RNAi against GFP were used.

ORGANISM(S): Homo sapiens

SUBMITTER: Jeffrey Parvin 

PROVIDER: E-GEOD-22259 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

BRCA1 represses amphiregulin gene expression.

Lamber Ekaterina P EP   Horwitz Andrew A AA   Parvin Jeffrey D JD  

Cancer research 20100126 3


BRCA1, the breast cancer- and ovarian cancer-specific tumor suppressor, can be a transcriptional repressor or a transcriptional activator, depending on the promoter context. To identify the genes activated or repressed by BRCA1, we have analyzed microarray results from cells depleted of BRCA1 and revealed a number of genes regulated by BRCA1 on the level of transcription. Among the genes repressed by BRCA1, we have identified amphiregulin (AREG) and early growth response-1 (EGR1). Results indica  ...[more]

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