Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Comparative transcriptomic analysis of prostate cancer and matched normal tissue using RNA-seq


ABSTRACT: We used RNA-seq to interrogate prostate cancer specific gene fusions, alternative splicings, somatic mutations and novel transcripts. We sequenced the transcriptome (polyA+) of 20 prostate cancer tumors and 10 matched normal tissues using Illumina GAII platform. Then we used bioinformatic approaches to identify prostate cancer specific aberrations which include gene fusion, alternative splicing, somatic mutation, etc.

ORGANISM(S): Homo sapiens

SUBMITTER: LIGUO WANG 

PROVIDER: E-GEOD-22260 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing.

Kannan Kalpana K   Wang Liguo L   Wang Jianghua J   Ittmann Michael M MM   Li Wei W   Yen Laising L  

Proceedings of the National Academy of Sciences of the United States of America 20110512 22


Transcription-induced chimeric RNAs, possessing sequences from different genes, are expected to increase the proteomic diversity through chimeric proteins or altered regulation. Despite their importance, few studies have focused on chimeric RNAs especially regarding their presence/roles in human cancers. By deep sequencing the transcriptome of 20 human prostate cancer and 10 matched benign prostate tissues, we obtained 1.3 billion sequence reads, which led to the identification of 2,369 chimeric  ...[more]

Similar Datasets

2011-02-08 | E-GEOD-22111 | biostudies-arrayexpress
2014-04-01 | E-GEOD-21696 | biostudies-arrayexpress
2014-04-01 | E-GEOD-47899 | biostudies-arrayexpress
2011-05-02 | GSE22260 | GEO
2012-04-26 | E-GEOD-28950 | biostudies-arrayexpress
2011-11-16 | E-GEOD-28264 | biostudies-arrayexpress
2012-06-29 | E-GEOD-26794 | biostudies-arrayexpress
| phs000554 | dbGaP
2012-04-26 | E-GEOD-28951 | biostudies-arrayexpress
2012-12-06 | E-GEOD-35342 | biostudies-arrayexpress