Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Doulaye Dembele
PROVIDER: E-GEOD-22280 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kusy Sophie S Gault Nathalie N Ferri Federica F Lewandowski Daniel D Barroca Vilma V Jaracz-Ros Agnieszka A Losson Regine R Romeo Paul-Henri PH
Cell stem cell 20110401 4
Crosstalk between transcription factors and cytokines precisely regulates tissue homeostasis. Transcriptional intermediary factor 1γ (TIF1γ) regulates vertebrate hematopoietic development, can control transcription elongation, and is a component of the TGF-β signaling pathway. Here we show that deletion of TIF1γ in adult hematopoiesis is compatible with life and long-term maintenance of essential blood cell lineages. However, loss of TIF1γ results in deficient long-term hematopoietic stem cell ( ...[more]