Shigella Apoptosis Arrays
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Douglas Scott Merrell
PROVIDER: E-GEOD-22287 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Microarray analysis of Shigella flexneri-infected epithelial cells identifies host factors important for apoptosis inhibition.
Faherty Christina S CS Merrell D Scott DS Semino-Mora Cristina C Dubois Andre A Ramaswamy Aishwarya V AV Maurelli Anthony T AT
BMC genomics 20100429
<h4>Background</h4>Shigella flexneri inhibits apoptosis in infected epithelial cells. In order to understand the pro-survival effects induced by the bacteria, we utilized apoptosis-specific microarrays to analyze the changes in eukaryotic gene expression in both infected and uninfected cells in the presence and absence of staurosporine, a chemical inducer of the intrinsic pathway of apoptosis. The goal of this research was to identify host factors that contribute to apoptosis inhibition in infec ...[more]
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