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Expression data from ileum of inducible intestine-specific GATA6 knockout mice

ABSTRACT: GATA6 is a transcription factor involved in the differentiation of intestinal epithelial cells into differentiated absorptive epithelial cells. GATA6 is expressed in all segments of the small intestine. We examined the impact of deleting GATA6 from intestinal epithelial cells of the adult ileum 6-8 week old Villin-CreERT2 mice or Villin-CreERT2 mice crossed to GATA6 flox/flox mice were treated with a single injection of tamoxifen. (100 mg/ml) for 5 consecutive days. 28 days later the ileum was dissected and RNA prepared from the whole ileal segment using the RNAeasy method with DNAse treatment. Three individual mice were examined in each of the control and GATA6 KO groups.

ORGANISM(S): Mus musculus

SUBMITTER: James Fleet 

PROVIDER: E-GEOD-22416 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice.

Beuling Eva E   Baffour-Awuah Nana Yaa A NY   Stapleton Kelly A KA   Aronson Boaz E BE   Noah Taeko K TK   Shroyer Noah F NF   Duncan Stephen A SA   Fleet James C JC   Krasinski Stephen D SD  

Gastroenterology 20110121 4

<h4>Background & aims</h4>GATA transcription factors regulate proliferation, differentiation, and gene expression in multiple organs. GATA4 is expressed in the proximal 85% of the small intestine and regulates the jejunal-ileal gradient in absorptive enterocyte gene expression. GATA6 is co-expressed with GATA4 but also is expressed in the ileum; its function in the mature small intestine is unknown.<h4>Methods</h4>We investigated the function of GATA6 in small intestine using adult mice with con  ...[more]

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