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Evolutionary conservation of nuclear lamina-genome interactions

ABSTRACT: Regulation of gene expression is highly conserved between vertebrates, yet the genomic binding patterns of transcription factors are poorly conserved, suggesting that other mechanisms may contribute. The spatial organization of chromosomes in the nucleus is known to affect gene activity, but it is unclear to what extent this organization is conserved in evolution. Genome-wide maps of nuclear lamina (NL) interactions show that human and mouse chromosomes have highly similar folding patterns inside the nucleus. Breaks in synteny are often located at transition points between NL interacting and intra-nuclear regions. Data were compared against data from Peric-Hupkes, Meuleman et al. (Molecular Cell, 2010). LaminB1-chromatin interactions were assayed in human ESCs and human HT1080 cells. LaminA-chromatin interactions were assayed in human HT1080 cells. For the all samples there were 2 biological replicates, that were hybridized in a dye-swap design.

ORGANISM(S): Homo sapiens

SUBMITTER: Bas van Steensel

PROVIDER: E-GEOD-22428 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Stochastic genome - nuclear lamina contacts are linked to histone H3K9 dimethylation (methylation data)

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2013-01-31 | E-GEOD-40094 | biostudies-arrayexpress

Stochastic genome-nuclear lamina interactions: Modulating roles of Lamin A and BAF

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Stochastic genome - nuclear lamina contacts are linked to histone H3K9 dimethylation

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