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Identifying Molecular Effects of Diet through Systems Biology: Influence of Herring Diet on Sterol Metabolism and Protein Turnover in Mice

ABSTRACT: Identifying molecular effects between herring and beef diet in Ldlr-/- mice The transcriptome of the three tissues, which are liver, muscle and adipose tissue, were used for indentify the influence of diet on metabolism. Ldlr-/- mice were fed with either a beef diet or a herring diet.

ORGANISM(S): Mus musculus

SUBMITTER: Intawat Nookaew

PROVIDER: E-GEOD-22532 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identifying molecular effects of diet through systems biology: influence of herring diet on sterol metabolism and protein turnover in mice.

Nookaew Intawat I Gabrielsson Britt G BG Holmäng Agneta A Sandberg Ann-Sofie AS Nielsen Jens J

PloS one 20100824 8

<h4>Background</h4>Changes in lifestyle have resulted in an epidemic development of obesity-related diseases that challenge the healthcare systems worldwide. To develop strategies to tackle this problem the focus is on diet to prevent the development of obesity-associated diseases such as cardiovascular disease (CVD). This will require methods for linking nutrient intake with specific metabolic processes in different tissues.<h4>Methodology/principal finding</h4>Low-density lipoprotein receptor- ...[more]

PMID: 20808764

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Identifying Molecular Effects of Diet through Systems Biology: Influence of Herring Diet on Sterol Metabolism and Protein Turnover in Mice

Project description:Identifying molecular effects between herring and beef diet in Ldlr-/- mice

2011-01-24 | GSE22532 | GEO

Transcriptome analysis of aortic valve tissues from hyperlipidemic and control mice with normal chow diet (chow) or western diet (WD)

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Gene expression in adipose, liver and skeletal muscle of mice fed a diet with c9, t11 conjugated linoleic acid enriched beef

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Effects of paternal high cholesterol diet on F1 generation intimal transcriptome

Project description:Purpose: To investigate the effects of paternal high cholesterol diet on the F1 intimal transcriptome related to atherosclerosis. Methods:Three-week-old male LDL Receptor-deficient (LDLR-/-) male mice were fed a low-cholesterol diet (LCD) or high-cholesterol diet (HCD) for 8 weeks and then mated with age-matched control LDLR-/- female mice to generate F1 offspring. F1 LDLR-/- mice were fed a LCD for 16 weeks. Intimal RNA was extracted by injecting Trizol into the aorta and collecting the flow through for further processing. Results: . Total RNA isolated from the F1 intima were then subjected for RNA-sequencing analysis and results show that paternal hypercholesterolemia led to upregulation of 147 genes in the intimal of F1 female mice, many of which are involved in immune and inflammatory pathways.

2024-10-08 | GSE251711 | GEO

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Project description:Diaph1 was knocked out in Ldlr-/- mice on western diet for 16 weeks and the effect of gene expression in liver was measured.

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Effects of high cholesterol diet on intimal transcriptome [Intima_mRNA]

Project description:Purpose: To investigate the effects of high cholesterol diet on the intimal transcriptome related to atherosclerosis. Methods: 3-week-old LDLR-/- male mice were fed a high cholesterol or low cholesterol diet for 9 weeks. Intimal RNA was extracted by injecting Trizol into the aorta and collecting the flow through for further processing. Results: Mice fed a high cholesterol revealed upregulation in atherosclerosis and immune/inflammatory related genes.

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The Effect of Camelina Oil-Containing Diets on the Expression of Genes Involved in the Innate Anti-Viral Immune Response in Atlantic Cod (Gadus Morhua)

Project description:This study was performed to investigate the effect of camelina oil-based diets on the immune function of Atlantic cod, as measured by gene expression in spleen. Atlantic cod were fed with one of three practical diets (three tanks per diet): a control diet using herring oil as a lipid source (FO diet), and two experimental diets using vegetable oil from Camelina sativa to replace 40% or 80% of herring oil (40CO and 80CO diets). We studied both the effect of the diet alone on basal spleen gene expression levels, as well as the effect of the diet after fish were injected with the synthetic double-stranded RNA polyriboinosinic polyribocytidylic acid (pIC), which mimics a viral immune stimulus.

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Identifying molecular effects of diet through systems biology: influence of herring diet on sterol metabolism and protein turnover in mice.

Project description:BackgroundChanges in lifestyle have resulted in an epidemic development of obesity-related diseases that challenge the healthcare systems worldwide. To develop strategies to tackle this problem the focus is on diet to prevent the development of obesity-associated diseases such as cardiovascular disease (CVD). This will require methods for linking nutrient intake with specific metabolic processes in different tissues.Methodology/principal findingLow-density lipoprotein receptor-deficient (Ldlr -/-) mice were fed a high fat/high sugar diet to mimic a westernized diet, being a major reason for development of obesity and atherosclerosis. The diets were supplemented with either beef or herring, and matched in macronutrient contents. Body composition, plasma lipids and aortic lesion areas were measured. Transcriptomes of metabolically important tissues, e.g. liver, muscle and adipose tissue were analyzed by an integrated approach with metabolic networks to directly map the metabolic effects of diet in these different tissues. Our analysis revealed a reduction in sterol metabolism and protein turnover at the transcriptional level in herring-fed mice.ConclusionThis study shows that an integrated analysis of transcriptome data using metabolic networks resulted in the identification of signature pathways. This could not have been achieved using standard clustering methods. In particular, this systems biology analysis could enrich the information content of biomedical or nutritional data where subtle changes in several tissues together affects body metabolism or disease progression. This could be applied to improve diets for subjects exposed to health risks associated with obesity.

| S-EPMC2927425 | biostudies-literature

Circadian Liver Gene Expression in Animals on Normal Chow or High Fat Diet

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2013-12-19 | E-GEOD-52333 | biostudies-arrayexpress

Macrophage recipient WGBS data: Donors infected with Porphyromonas gingivali (WDPg) or sham-infected (WD) and fed a western diet (WD)

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