Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human lens epithelial cells and lens cortical fiber cells


ABSTRACT: Total RNA was isolated from three separate populations of human lens epithelial cells and three matching populations of lens cortical fiber cells. All samples were analyzed on separate microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: John Hawse 

PROVIDER: E-GEOD-2256 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of global gene expression differences between human lens epithelial and cortical fiber cells reveals specific genes and their associated pathways important for specialized lens cell functions.

Hawse John R JR   DeAmicis-Tress Candida C   Cowell Tracy L TL   Kantorow Marc M  

Molecular vision 20050418


<h4>Purpose</h4>In order to identify specific genes that may play important roles in maintaining the specialized functions of lens epithelial and fiber cells, we have analyzed the global gene expression profiles of these two cell types in the human lens. This analysis will also reveal those genes that are exclusively expressed in the epithelial and cortical fiber cells and those genes that may play important roles in the differentiation of epithelial cells to mature fiber cells.<h4>Methods</h4>O  ...[more]

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