Changes in Hepatic Gene Expression upon Oral Administration of Taurine-Conjugated Ursodeoxycholic Acid in ob/ob Mice
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ABSTRACT: We examined the effect of oral TUDCA treatment on hepatic steatosis and associated changes in hepatic gene expression in ob/ob mice. We administered TUDCA to ob/ob mice at a dose of 500 mg/kg twice a day by gastric gavage for 3 weeks. Body weight, glucose homeostasis, endoplasmic reticulum (ER) stress, and hepatic gene expression were examined in comparison with control ob/ob mice and normal littermate C57BL/6J mice.
ORGANISM(S): Mus musculus
SUBMITTER: Jae-Seong Yang
PROVIDER: E-GEOD-22608 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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