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Unknown,Transcriptomics,Genomics,Proteomics

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Drosophila Pph13 mutant vs. wildtype and Orthodenticle, Pph13 double mutant vs. wildtype

ABSTRACT: Transcriptional profiling of Drosophila eye mutants Pph13 and orthodenticle Total head RNA cn bw vs. Pph13 cn bw and cn bw vs. otd; Pph13 cn bw at various developmental time points

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Andrew Zelhof

PROVIDER: E-GEOD-22613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function.

Mishra Monalisa M Oke Ashwini A Lebel Cindy C McDonald Elizabeth C EC Plummer Zachary Z Cook Tiffany A TA Zelhof Andrew C AC

Development (Cambridge, England) 20100728 17

The function and integrity of photoreceptor cells are dependent upon the creation and maintenance of specialized apical structures: membrane discs/outer segments in vertebrates and rhabdomeres in insects. We performed a molecular and morphological comparison of Drosophila Pph13 and orthodenticle (otd) mutants to investigate the transcriptional network controlling the late stages of rhabdomeric photoreceptor cell development and function. Although Otd and Pph13 have been implicated in rhabdomere ...[more]

PMID: 20667913

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