Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Ryan Dale
PROVIDER: E-GEOD-22623 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Moshkovich Nellie N Nisha Parul P Boyle Patrick J PJ Thompson Brandi A BA Dale Ryan K RK Lei Elissa P EP
Genes & development 20110801 16
A major role of the RNAi pathway in Schizosaccharomyces pombe is to nucleate heterochromatin, but it remains unclear whether this mechanism is conserved. To address this question in Drosophila, we performed genome-wide localization of Argonaute2 (AGO2) by chromatin immunoprecipitation (ChIP)-seq in two different embryonic cell lines and found that AGO2 localizes to euchromatin but not heterochromatin. This localization pattern is further supported by immunofluorescence staining of polytene chrom ...[more]