Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ming-Sound Tsao
PROVIDER: E-GEOD-22863 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Navab Roya R Strumpf Dan D Bandarchi Bizhan B Zhu Chang-Qi CQ Pintilie Melania M Ramnarine Varune Rohan VR Ibrahimov Emin E Radulovich Nikolina N Leung Lisa L Barczyk Malgorzata M Panchal Devang D To Christine C Yun James J JJ Der Sandy S Shepherd Frances A FA Jurisica Igor I Tsao Ming-Sound MS
Proceedings of the National Academy of Sciences of the United States of America 20110407 17
The tumor microenvironment strongly influences cancer development, progression, and metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and their clinical impact has not been studied systematically in non-small cell lung carcinoma (NSCLC). We established primary cultures of CAFs and matched normal fibroblasts (NFs) from 15 resected NSCLC. We demonstrate that CAFs have greater ability than NFs to enhance the tumorigenicity of lung cancer cell lines. Microarray gene- ...[more]