Genome-wide analysis of Ollier disease: Is it all in the genes?
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Twinkal Pansuriya
PROVIDER: E-GEOD-22965 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide analysis of Ollier disease: Is it all in the genes?
Pansuriya Twinkal C TC Oosting Jan J Krenács Tibor T Taminiau Antonie H M AH Verdegaal Suzan H M SH Sangiorgi Luca L Sciot Raf R Hogendoorn Pancras C W PC Szuhai Karoly K Bovée Judith V M G JV
Orphanet journal of rare diseases 20110114
<h4>Background</h4>Ollier disease is a rare, non-hereditary disorder which is characterized by the presence of multiple enchondromas (ECs), benign cartilaginous neoplasms arising within the medulla of the bone, with an asymmetric distribution. The risk of malignant transformation towards central chondrosarcoma (CS) is increased up to 35%. The aetiology of Ollier disease is unknown.<h4>Methods</h4>We undertook genome-wide copy number and loss of heterozygosity (LOH) analysis using Affymetrix SNP ...[more]
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