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Transcription profiling of human HLE B-3 cells transfected with hGSTA4-4 expressing vector vs. controls

ABSTRACT: HLE B-3 cells were transfected with either empty vector or hGSTA4-4 expressing vector to lower intracellular 4-hydroxynonenal levels. hGSTA4-transfected sample has lower HNE levels than pTarget-transfected sample.

ORGANISM(S): Homo sapiens

SUBMITTER: Brad Allen Patrick 

PROVIDER: E-GEOD-2298 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression.

Patrick Brad B   Li Jie J   Jeyabal Prince V S PV   Reddy Prasada M R V PM   Yang Yusong Y   Sharma Rajendra R   Sinha Mala M   Luxon Bruce B   Zimniak Piotr P   Awasthi Sanjay S   Awasthi Yogesh C YC  

Biochemical and biophysical research communications 20050801 2

Previously, we have shown that overexpression of 4-hydroxy-2-nonenal (HNE)-detoxifying enzyme glutathione S-transferase A4-4 (hGSTA4-4) in human lens epithelial cells (HLE B-3) leads to pro-carcinogenic phenotypic transformation of these cells [R. Sharma, et al. Eur. J. Biochem. 271 (2004) 1960-1701]. We now demonstrate that hGSTA4-transfection also causes a profound change in the expression of genes involved in cell adhesion, cell cycle control, proliferation, cell growth, and apoptosis, which  ...[more]

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