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Transcriptional profiling of a wound healing process in skin and oral mucosa

ABSTRACT: When compared to skin, oral mucosal wounds heal rapidly and with reduced scar formation. This study used an Affymetrix microarray platform to compare the transcriptomes of oral mucosa and skin wounds in order to identify critical differences in the healing response at these two sites. Using microarrays, we explored the differences in gene expression in skin and oral mucosal wound healing in a murine model of paired equivalent-sized wounds. Samples were examined from day 0 to day 10 and spanned all stages of the wound healing process. Unwounded matched tissue was used as a control. Tissue samples collected at each post-wounding time point, as well as control samples, were represented by 3 biological replicates.

ORGANISM(S): Mus musculus

SUBMITTER: Zarema Arbieva

PROVIDER: E-GEOD-23006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Positional differences in the wound transcriptome of skin and oral mucosa.

Chen Lin L Arbieva Zarema H ZH Guo Shujuan S Marucha Phillip T PT Mustoe Thomas A TA DiPietro Luisa A LA

BMC genomics 20100812

<h4>Background</h4>When compared to skin, oral mucosal wounds heal rapidly and with reduced scar formation. Recent studies suggest that intrinsic differences in inflammation, growth factor production, levels of stem cells, and cellular proliferation capacity may underlie the exceptional healing that occurs in oral mucosa. The current study was designed to compare the transcriptomes of oral mucosal and skin wounds in order to identify critical differences in the healing response at these two site ...[more]

PMID: 20704739

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