Unknown,Transcriptomics,Genomics,Proteomics

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Gene transcription in carbamazepine- and minocycline-induced DRESS


ABSTRACT: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe, drug-induced reaction that involves both the skin and viscera. To understand the immunological components of DRESS, we prospectively assessed 40 DRESS patients. The patients were evaluated for phenotype, cytokine secretion, repertoire of CD4+ and CD8+ peripheral blood T lymphocytes and viral reactivation. A subgroup of patients was analyzed using microarrays. Patients with carbamazepine- or minocycline- induced DRESS were pooled separately for analysis. RNA from total PBMCs and CD4+ and CD8+-sorted blood T cells was amplified. Expression of 894 genes of immunological interest was analyzed with a PIQOR TM arrays (Miltenyi). Gene expression was individually compared between day 0 and 90 in the minocycline-induced DRESS patients. Control groups included patients taking minocycline carbamazepine, and healthy patients without medication.

ORGANISM(S): Homo sapiens

SUBMITTER: Baptiste JANELA 

PROVIDER: E-GEOD-23015 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Drug reaction with eosinophilia and systemic symptoms (DRESS): a multiorgan antiviral T cell response.

Picard Damien D   Janela Baptiste B   Descamps Vincent V   D'Incan Michel M   Courville Philippe P   Jacquot Serge S   Rogez Sylvie S   Mardivirin Laurent L   Moins-Teisserenc Hélène H   Toubert Antoine A   Benichou Jacques J   Joly Pascal P   Musette Philippe P  

Science translational medicine 20100801 46


Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, drug-induced reaction that involves both the skin and the viscera. Evidence for reactivation of herpes family viruses has been seen in some DRESS patients. To understand the immunological components of DRESS and their relationship to viral reactivation, we prospectively assessed 40 patients exhibiting DRESS in response to carbamazepine, allopurinol, or sulfamethoxazole. Peripheral blood T lymphocytes from the patients wer  ...[more]

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