Different propensity in hematopoietic differentiation potential among distinct human pluripotent stem cell lines

ABSTRACT: Lineage-specific differentiation potential varies among different human pluripotent stem cell (hPSC) lines. A stem cell bank may advice researchers on which hPSCs exhibit the highest differentiation potential for a certain lineage. In this study, we aimed at characterizing the hematopoietic differentiation potential from 14 hESC/iPSC lines through the embryoid body (hEB) differentiation system. We carried out gene expression profiling on six different hESC lines grouped according to their ability to differentiate towards hematopoietic lineage: SHEF1, AND1 and H1 were considered as good (high CD45 expression and high CFU potential), whereas H9, HS181 and VAL3 were selected as poor-blood differentiating lines (low CD45 expression and low CFU potential). Human ESC samples were collected durin

ORGANISM(S): Homo sapiens

SUBMITTER: Gustavo Melen 

PROVIDER: E-GEOD-23091 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress