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DNA methylation data from mouse hematopoietic progenitors

ABSTRACT: Genome-wide DNA methylation was studied to determine the methylome map of lymphoid and myeoloid commitment from hematopoietic progenitors We used custom Nimblegen microarrays to determine the genome-wide DNA methylation in FACs purified mouse hematopoietic progeniors We isolated genomic DNA from mouse MPPFL-, MPPFL+, CLP, DN1, DN2, DN3, CMP and GMP cells and hybridized to custom-designed Nimblegen microarrays (CHARM arrays).

ORGANISM(S): Mus musculus

SUBMITTER: Hong Ji 

PROVIDER: E-GEOD-23110 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged. Haematopoiesis provides a well-defined model to study epigenetic modifications during cell-fate decisions, as multipotent progenitors (MPPs) differentiate into progressively restricted myeloid or lymphoid progenitors. Although DNA methylation is critical for myeloid versus lymphoid differentiation, as demonstrated by the my  ...[more]

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