Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of A.E7 T cells to identify early growth response genes Egr-2 and Egr-3 as key negative regulators of T cell activation


ABSTRACT: pooled mRNA (2, 4, 6 hrs) from A.E7 T cells under conditions which promote or inhibit anergy induction

ORGANISM(S): Mus musculus

SUBMITTER: Michael Lutz 

PROVIDER: E-GEOD-2323 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy. E3 ligases are involved in maintaining the anergic state. However, the specific molecules responsible for the induction of anergy have yet to be elucidated. Using microarray analysis we have identified here early growth response gene 2 (Egr-2) and Egr-3 as key negative regulators of T cell activation. Overexpression of Egr2 and Egr3 was associated with an increase in the E3 ubiquitin ligase Cbl-b and in  ...[more]

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