Histone H4 N-terminal tail mutants
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Oliver Rando
PROVIDER: E-GEOD-2324 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomic characterization reveals a simple histone H4 acetylation code.
Dion Michael F MF Altschuler Steven J SJ Wu Lani F LF Rando Oliver J OJ
Proceedings of the National Academy of Sciences of the United States of America 20050328 15
The histone code hypothesis holds that covalent posttranslational modifications of histone tails are interpreted by the cell to yield a rich combinatorial transcriptional output. This hypothesis has been the subject of active debate in the literature. Here, we investigated the combinatorial complexity of the acetylation code at the four lysine residues of the histone H4 tail in budding yeast. We constructed yeast strains carrying all 15 possible combinations of mutations among lysines 5, 8, 12, ...[more]
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