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Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE23384: Gene profiling using archival formalin-fixed paraffin-embedded breast cancer specimens can generate informative microarray data: A comparison with matched fresh fine needle aspiration biopsy samples (FFPE samples) GSE23385: Gene profiling using archival formalin-fixed paraffin-embedded breast cancer specimens can generate informative microarray data: A comparison with matched fresh fine needle aspiration biopsy samples (FNA samples) Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Dong-Yu Wang

PROVIDER: E-GEOD-23386 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens.

Sadi Al Muktafi AM Wang Dong-Yu DY Youngson Bruce J BJ Miller Naomi N Boerner Scott S Done Susan J SJ Leong Wey L WL

BMC cancer 20110616

<h4>Background</h4>The ability of gene profiling to predict treatment response and prognosis in breast cancers has been demonstrated in many studies using DNA microarray analyses on RNA from fresh frozen tumor specimens. In certain clinical and research situations, performing such analyses on archival formalin fixed paraffin-embedded (FFPE) surgical specimens would be advantageous as large libraries of such specimens with long-term follow-up data are widely available. However, FFPE tissue proces ...[more]

PMID: 21679412

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