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Transcription profiling of human normal and transformed mature B cells

ABSTRACT: Phenotypes representative of normal, transformed and experimentally manipulated human B cells related to the germinal center structure.

ORGANISM(S): Homo sapiens

SUBMITTER: Katia Basso

PROVIDER: E-GEOD-2350 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Reverse engineering of regulatory networks in human B cells.

Basso Katia K Margolin Adam A AA Stolovitzky Gustavo G Klein Ulf U Dalla-Favera Riccardo R Califano Andrea A

Nature genetics 20050320 4

Cellular phenotypes are determined by the differential activity of networks linking coregulated genes. Available methods for the reverse engineering of such networks from genome-wide expression profiles have been successful only in the analysis of lower eukaryotes with simple genomes. Using a new method called ARACNe (algorithm for the reconstruction of accurate cellular networks), we report the reconstruction of regulatory networks from expression profiles of human B cells. The results are sugg ...[more]

PMID: 15778709

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