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Microarray Analysis Reveals Distinct Gene Expression Profiles Among Different Tumor Histology, Stage and Disease Outcomes in Endometrial Adenocarcinoma

ABSTRACT: The goal of this study was to identify differentially expressed genes (DEG) between early vs. late stage endometrioid adenocarcinoma (EAC) and uterine serous carcinoma (USC), as well as between disease outcomes in each of the two histological subtypes. Gene expression profiles of 20 cancer samples were analyzed (EAC =10, USC =10) using the human genome wide illumina bead microarrays carrying 48,000 genes.

ORGANISM(S): Homo sapiens

SUBMITTER: song liu

PROVIDER: E-GEOD-23518 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Microarray analysis reveals distinct gene expression profiles among different tumor histology, stage and disease outcomes in endometrial adenocarcinoma.

Mhawech-Fauceglia Paulette P Wang Dan D Kesterson Joshua J Clark Kimberly K Monhollen Laketa L Odunsi Kunle K Lele Shashikant S Liu Song S

PloS one 20101108 11

<h4>Background</h4>Endometrial cancer is the most common gynecologic malignancy in developed countries and little is known about the underlying mechanism of stage and disease outcomes. The goal of this study was to identify differentially expressed genes (DEG) between late vs. early stage endometrioid adenocarcinoma (EAC) and uterine serous carcinoma (USC), as well as between disease outcomes in each of the two histological subtypes.<h4>Methodology/principal finding</h4>Gene expression profiles ...[more]

PMID: 21079744

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