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Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set

ABSTRACT: We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD). Lung specimens were obtained from patients with a variety of lung diseases. After resection, tissue samples of the lobes or lungs not relevant for the diagnostic work-up were frozen and stored at -80C. RNAs were extracted and then hybridized to a single custom-made whole-genome human Affymetrix array.

ORGANISM(S): Homo sapiens

SUBMITTER: Yohan Bossé

PROVIDER: E-GEOD-23545 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular signature of smoking in human lung tissues.

Bossé Yohan Y Postma Dirkje S DS Sin Don D DD Lamontagne Maxime M Couture Christian C Gaudreault Nathalie N Joubert Philippe P Wong Vivien V Elliott Mark M van den Berge Maarten M Brandsma Corry A CA Tribouley Catherine C Malkov Vladislav V Tsou Jeffrey A JA Opiteck Gregory J GJ Hogg James C JC Sandford Andrew J AJ Timens Wim W Paré Peter D PD Laviolette Michel M

Cancer research 20120601 15

Cigarette smoking is the leading risk factor for lung cancer. To identify genes deregulated by smoking and to distinguish gene expression changes that are reversible and persistent following smoking cessation, we carried out genome-wide gene expression profiling on nontumor lung tissue from 853 patients with lung cancer. Gene expression levels were compared between never and current smokers, and time-dependent changes in gene expression were studied in former smokers. A total of 3,223 transcript ...[more]

PMID: 22659451

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