Molecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Carolina Gustavsson
PROVIDER: E-GEOD-23810 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Sex-dependent hepatic transcripts and metabolites in the development of glucose intolerance and insulin resistance in Zucker diabetic fatty rats.
Gustavsson Carolina C Soga Tomoyoshi T Wahlström Erik E Vesterlund Mattias M Azimi Alireza A Norstedt Gunnar G Tollet-Egnell Petra P
Journal of molecular endocrinology 20110825 2
Male Zucker diabetic fatty (mZDF) rats spontaneously develop type 2 diabetes, whereas females only become diabetic when fed a diabetogenic high-fat diet (high-fat-fed female ZDF rat, HF-fZDF). The aim of this study was to investigate if differences in liver functions could provide clues to this sex difference. Non-diabetic obese fZDF rats were compared with either mZDF or HF-fZDF regarding hepatic molecular profiles, to single out those components that might be protective in the females. High-fa ...[more]
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