Ontology highlight
ABSTRACT:
ORGANISM(S): Candida glabrata
SUBMITTER: Dominique Sanglard
PROVIDER: E-GEOD-23827 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ferrari Sélène S Sanguinetti Maurizio M Torelli Riccardo R Posteraro Brunella B Sanglard Dominique D
PloS one 20110309 3
In Candida glabrata, the transcription factor CgPdr1 is involved in resistance to azole antifungals via upregulation of ATP binding cassette (ABC)-transporter genes including at least CgCDR1, CgCDR2 and CgSNQ2. A high diversity of GOF (gain-of-function) mutations in CgPDR1 exists for the upregulation of ABC-transporters. These mutations enhance C. glabrata virulence in animal models, thus indicating that CgPDR1 might regulate the expression of yet unidentified virulence factors. We hypothesized ...[more]