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Expression profiles of PBMC from multiple sclerosis patients

ABSTRACT: Affymetrix GeneChip Human Gene 1.0 ST Array was applied to compare the expression profiles in peripheral blood mononuclear cells(PBMC) between healthy controls and multiple sclerosis patients(MS pt). It suggested that certain genes involved in apoptosis pathway have been changed regulated in PBMC from MS pt. Applying Affymetrix GeneChip Human Gene 1.0 ST Array and the mixed effects model for gene set analysis, we compared gene expression profiles between 8 multiple sclerosis (MS) patients and 4 healthy controls (HC).

ORGANISM(S): Homo sapiens

SUBMITTER: Fanglin Zhang 

PROVIDER: E-GEOD-23832 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis.

Zhang Fanglin F   Shi Yaping Y   Wang Lily L   Sriram Subramaniam S  

PloS one 20110208 2

<h4>Background</h4>Histone deacetylase 3 (HDAC3) belongs to a family of proteins which plays an important role in protein acetylation, chromatin remodeling and transcription of genes, including those that are involved in cell proliferation and cell death. While increased expression of HDAC3 is seen in neoplastic cells, the role of HDAC3 in T cells and their role in autoimmune disease is not known.<h4>Methodology/principal findings</h4>Applying Affymetrix GeneChip Human Gene 1.0 ST Array and the  ...[more]

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