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Transcription profiling of nasal epithelium from CF patients with mild and severe cystic fibrosis lung disease to identify candidate genes that influence the severity of pulmonary disease and to identify genes indicative of CF disease progression

ABSTRACT: Summary: CF patients homozygous for the DF08 DF08 genotype present a full range of phenotypic manifestations that exist within the pulmonary system. This project aims to identify candidate genes that influence the severity of pulmonary disease; Hypothesis: The goal is to find genes predictive of progression in CF. More information can be found at http://www.hopkins-genomics.org/cf/cf001/index.html

ORGANISM(S): Homo sapiens

DISEASE(S): mild cystic fibrosis, pulmonary disease

SUBMITTER: Eric Hoffman

PROVIDER: E-GEOD-2395 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease.

Wright Jerry M JM Merlo Christian A CA Reynolds Jeffrey B JB Zeitlin Pamela L PL Garcia Joe G N JG Guggino William B WB Boyle Michael P MP

American journal of respiratory cell and molecular biology 20060413 3

Despite having identical cystic fibrosis transmembrane conductance regulator genotypes, individuals with DeltaF508 homozygous cystic fibrosis (CF) demonstrate significant variability in severity of pulmonary disease. This investigation used high-density oligonucleotide microarray analysis of nasal respiratory epithelium to investigate the molecular basis of phenotypic differences in CF by (1) identifying differences in gene expression between DeltaF508 homozygotes in the most severe 20th percent ...[more]

PMID: 16614352

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