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Gene expression profiles of splenocytes of CD22DE12 transgenic mice

ABSTRACT: Splenocytes from nontransgenic control mice and transgenic mice were isolated and their gene expression profiles were compared to determine if the expression of the transgene results in any changes in regulation of gene expression. 12 differentially expressed genes were classified as the most discriminating genes, including TP53, NF2, MDM2, RAC1, APC, and STATB1 with tumor suppressor gene function as well as cell cycle regulatory genes CDKN1C, CCNG1, and NOTCH4 Mice were sacrificed at 6 weeks of age, spleens removed, splenocytes isolated, and RNA extracted from splenocytes. Mouse ATLAS cDNA expression arrays were used for gene expression profiling.

ORGANISM(S): Mus musculus

SUBMITTER: Sanjive Qazi 

PROVIDER: E-GEOD-23998 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia.

Uckun Fatih M FM   Goodman Patricia P   Ma Hong H   Dibirdik Ilker I   Qazi Sanjive S  

Proceedings of the National Academy of Sciences of the United States of America 20100914 39

Here, we report that primary leukemic cells from infants with newly diagnosed B-precursor leukemia express a truncated and functionally defective CD22 coreceptor protein that is unable to transmit apoptotic signals because it lacks most of the intracellular domain, including the key regulatory signal transduction elements and all of the cytoplasmic tyrosine residues. Expression of this structurally and functionally abnormal CD22 protein is associated with a very aggressive in vivo growth of pati  ...[more]

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