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Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection

ABSTRACT: Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understand Mechanisms of Chemical Toxicity and Action These data support the publication titled "Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understand Mechanisms of Chemical Toxicity and Action" Copyright (c) 2005 by Iconix Pharmaceuticals, Inc. Guidelines for commercial use: http://www.iconixbiosciences.com/guidelineCommUse.pdf Keywords: other

ORGANISM(S): Rattus norvegicus

SUBMITTER: Mark Fielden 

PROVIDER: E-GEOD-2409 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action.

Ganter Brigitte B   Tugendreich Stuart S   Pearson Cecelia I CI   Ayanoglu Eser E   Baumhueter Susanne S   Bostian Keith A KA   Brady Lindsay L   Browne Leslie J LJ   Calvin John T JT   Day Gwo-Jen GJ   Breckenridge Naiomi N   Dunlea Shane S   Eynon Barrett P BP   Furness L Mike LM   Ferng Joe J   Fielden Mark R MR   Fujimoto Susan Y SY   Gong Li L   Hu Christopher C   Idury Radha R   Judo Michael S B MS   Kolaja Kyle L KL   Lee May D MD   McSorley Christopher C   Minor James M JM   Nair Ramesh V RV   Natsoulis Georges G   Nguyen Peter P   Nicholson Simone M SM   Pham Hang H   Roter Alan H AH   Sun Dongxu D   Tan Siqi S   Thode Silke S   Tolley Alexander M AM   Vladimirova Antoaneta A   Yang Jian J   Zhou Zhiming Z   Jarnagin Kurt K  

Journal of biotechnology 20050901 3

Successful drug discovery requires accurate decision making in order to advance the best candidates from initial lead identification to final approval. Chemogenomics, the use of genomic tools in pharmacology and toxicology, offers a promising enhancement to traditional methods of target identification/validation, lead identification, efficacy evaluation, and toxicity assessment. To realize the value of chemogenomics information, a contextual database is needed to relate the physiological outcome  ...[more]

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