Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of skeletal muscle gene expression in mice with C26 tumor-induced muscle wasting and cachexia


ABSTRACT: Analysis of gene expression in CD2F1 mice with cancer cachexia due to implantation of C26 colon carcinoma cells. Total RNA obtained from quadriceps muscle of female CD2F1 mice with early weight loss (10%) or severe weight loss (15%) due to intrascapular subcutaneous implantation of one million C26 colon adenocarcinoma cells.

ORGANISM(S): Mus musculus

SUBMITTER: Teresa Zimmers 

PROVIDER: E-GEOD-24112 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia.

Bonetto Andrea A   Aydogdu Tufan T   Kunzevitzky Noelia N   Guttridge Denis C DC   Khuri Sawsan S   Koniaris Leonidas G LG   Zimmers Teresa A TA  

PloS one 20110720 7


<h4>Background</h4>Cachexia, or weight loss despite adequate nutrition, significantly impairs quality of life and response to therapy in cancer patients. In cancer patients, skeletal muscle wasting, weight loss and mortality are all positively associated with increased serum cytokines, particularly Interleukin-6 (IL-6), and the presence of the acute phase response. Acute phase proteins, including fibrinogen and serum amyloid A (SAA) are synthesized by hepatocytes in response to IL-6 as part of t  ...[more]

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