Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Teresa Zimmers
PROVIDER: E-GEOD-24112 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bonetto Andrea A Aydogdu Tufan T Kunzevitzky Noelia N Guttridge Denis C DC Khuri Sawsan S Koniaris Leonidas G LG Zimmers Teresa A TA
PloS one 20110720 7
<h4>Background</h4>Cachexia, or weight loss despite adequate nutrition, significantly impairs quality of life and response to therapy in cancer patients. In cancer patients, skeletal muscle wasting, weight loss and mortality are all positively associated with increased serum cytokines, particularly Interleukin-6 (IL-6), and the presence of the acute phase response. Acute phase proteins, including fibrinogen and serum amyloid A (SAA) are synthesized by hepatocytes in response to IL-6 as part of t ...[more]