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Unknown,Transcriptomics,Genomics,Proteomics

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Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE24186: Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Steroltalk platform] GSE24187: Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix platform] Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Juvan

PROVIDER: E-GEOD-24188 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The human primary hepatocyte transcriptome reveals novel insights into atorvastatin and rosuvastatin action.

Hafner Mateja M Juvan Peter P Rezen Tadeja T Monostory Katalin K Pascussi Jean-Marc JM Rozman Damjana D

Pharmacogenetics and genomics 20111101 11

<h4>Objectives</h4>With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well as a model substance for induction of nuclear pregnane X receptor.<h4>Methods</h4>Hepatocytes from human donors have been treated with rosuvastatin, atorvastatin, and rifampicin for ...[more]

PMID: 21869732

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Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix platform]

Project description:With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well as a model substance for induction of nuclear receptor PXR. Expression profiling with Affymetrix whole genome arrays shows that statins induce extensive transcriptome changes. 7 condition experiment: 3 treatments (atorvastatin, rifampicin, rosuvastatin), each measured at 2 time points (24 and 48 hours), and untreated cells. 4-6 biological replicates for each condition.

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Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix platform]

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Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Steroltalk platform]

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