2h dose response_AFB treatment
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Yingying Guo
PROVIDER: E-GEOD-2419 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarrays.
Guo Yingying Y Breeden Linda L LL Fan Wenhong W Zhao Lue Ping LP Eaton David L DL Zarbl Helmut H
Mutation research 20050824 1-2
Aflatoxin B1 (AFB(1)) is a potent human hepatotoxin and hepatocarcinogen produced by the mold Aspergillus flavus. In human, AFB(1) is bioactivated by cytochrome P450 (CYP450) enzymes, primarily CYP1A2, to the genotoxic epoxide that forms N(7)-guanine DNA adducts. To characterize the transcriptional responses to genotoxic insults from AFB(1), a strain of Saccharomyces cerevisiae engineered to express human CYP1A2 was exposed to doses of AFB(1) that resulted in minimal lethality, but substantial g ...[more]
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