Validated Gene Expression Signatures of Idiopathic Pulmonary Fibrosis

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease that is difficult to diagnose and follows an unpredictable clinical course. The object of this study was to develop a predictive gene signature model of IPF from whole lung tissue. We collected whole lung samples from 11 IPF patients undergoing diagnostic surgical biopsy or transplantation. Whenever possible, samples were obtained from different lobes. Normals consisted of healthy organs donated for transplantation. We measured gene expression on microarrays. Data were analyzed by hierarchical clustering and Principal Component Analysis. By this approach, we found that gene expression was similar in the upper and lower lobes of individuals with IPF. We also found that biopsied and explanted specimens contained differen

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Meltzer 

PROVIDER: E-GEOD-24206 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress