Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Eran Meshorer
PROVIDER: E-GEOD-24211 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of biological chemistry 20110817 41
Embryonic stem cell (ESC) chromatin is characterized by a unique set of histone modifications, including enrichment for H3 lysine 9 acetylation (H3K9ac). Recent studies suggest that histone deacetylase (HDAC) inhibitors promote pluripotency. Here, using H3K9ac ChIP followed by high throughput sequencing analyses and gene expression in E14 mouse ESCs before and after treatment with a low level of the HDAC inhibitor valproic acid, we show that H3K9ac is enriched at gene promoters and is highly cor ...[more]