MiRNA profiling in adult rat cardiomyocytes and myocyte-derived progenitor cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Yiqiang Zhang
PROVIDER: E-GEOD-24252 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dedifferentiation and proliferation of mammalian cardiomyocytes.
Zhang Yiqiang Y Li Tao-Sheng TS Lee Shuo-Tsan ST Wawrowsky Kolja A KA Cheng Ke K Galang Giselle G Malliaras Konstantinos K Abraham M Roselle MR Wang Charles C Marbán Eduardo E
PloS one 20100903 9
<h4>Background</h4>It has long been thought that mammalian cardiomyocytes are terminally-differentiated and unable to proliferate. However, myocytes in more primitive animals such as zebrafish are able to dedifferentiate and proliferate to regenerate amputated cardiac muscle.<h4>Methodology/principal findings</h4>Here we test the hypothesis that mature mammalian cardiomyocytes retain substantial cellular plasticity, including the ability to dedifferentiate, proliferate, and acquire progenitor ce ...[more]
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