Unknown,Transcriptomics,Genomics,Proteomics

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Deep transcriptional sequencing analysis of human prostate adenocarcinoma and reference samples


ABSTRACT: Prostate adenocarcinoma and matched adjacent normal samples were profiled by deep transcriptional sequencing to analyze transcription-induced chimeras and gene fusions. Reference samples from the MAQC and brain and universal reference libraries were also sequenced. Two-condition experiment plus reference samples: Prostate adenocarcinoma versus matched normal from three separate patients, plus brain and universal reference samples from the MAQC project.

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Wu 

PROVIDER: E-GEOD-24283 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples.

Nacu Serban S   Yuan Wenlin W   Kan Zhengyan Z   Bhatt Deepali D   Rivers Celina Sanchez CS   Stinson Jeremy J   Peters Brock A BA   Modrusan Zora Z   Jung Kenneth K   Seshagiri Somasekar S   Wu Thomas D TD  

BMC medical genomics 20110124


<h4>Background</h4>Readthrough fusions across adjacent genes in the genome, or transcription-induced chimeras (TICs), have been estimated using expressed sequence tag (EST) libraries to involve 4-6% of all genes. Deep transcriptional sequencing (RNA-Seq) now makes it possible to study the occurrence and expression levels of TICs in individual samples across the genome.<h4>Methods</h4>We performed single-end RNA-Seq on three human prostate adenocarcinoma samples and their corresponding normal tis  ...[more]

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