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R2d2 Ago1 Immunoprecipitation ovary

ABSTRACT: modENCODE_submission_2749 This submission comes from a modENCODE project of Eric Lai. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We plan to generate a comprehensive catalog of expressed and functional microRNAs, and generate biological evidence for their regulatory activity. We plan also to delineate the primary transcription units of microRNA genes. Finally, we plan to annotate other classes of non-miRNA expressed small RNAs, as least some of which may define novel classes of small RNA genes. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf Keywords: RIP-seq EXPERIMENT TYPE: RIP-seq. BIOLOGICAL SOURCE: Strain: r2d2 1; Developmental Stage: Adult Female; Genotype: w; r2d2[1]; Sb/TM6B; Sex: Female; EXPERIMENTAL FACTORS: Adult_ovaries

ORGANISM(S): Drosophila melanogaster

SUBMITTER: DCC modENCODE 

PROVIDER: E-GEOD-24313 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

R2D2 organizes small regulatory RNA pathways in Drosophila.

Okamura Katsutomo K   Robine Nicolas N   Liu Ying Y   Liu Qinghua Q   Lai Eric C EC  

Molecular and cellular biology 20101206 4

Drosophila microRNAs (miRNAs) and small interfering RNAs (siRNAs) are generally produced by different Dicer enzymes (Dcr-1 and Dcr-2) and sorted to functionally distinct Argonaute effectors (AGO1 and AGO2). However, there is cross talk between these pathways, as highlighted by the recognition that Drosophila miRNA* strands (the partner strands of mature miRNAs) are generated by Dcr-1 but are preferentially sorted to AGO2. Here, we show that a component of the siRNA loading complex, R2D2, is esse  ...[more]

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