Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): androgen-dependent prostate cancer
SUBMITTER: Carolyn Best
PROVIDER: E-GEOD-2443 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Best Carolyn J M CJ Gillespie John W JW Yi Yajun Y Chandramouli Gadisetti V R GV Perlmutter Mark A MA Gathright Yvonne Y Erickson Heidi S HS Georgevich Lauren L Tangrea Michael A MA Duray Paul H PH González Sergio S Velasco Alfredo A Linehan W Marston WM Matusik Robert J RJ Price Douglas K DK Figg William D WD Emmert-Buck Michael R MR Chuaqui Rodrigo F RF
Clinical cancer research : an official journal of the American Association for Cancer Research 20051001 19 Pt 1
<h4>Purpose</h4>After an initial response to androgen ablation, most prostate tumors recur, ultimately progressing to highly aggressive androgen-independent cancer. The molecular mechanisms underlying progression are not well known in part due to the rarity of androgen-independent samples from primary and metastatic sites.<h4>Experimental design</h4>We compared the gene expression profiles of 10 androgen-independent primary prostate tumor biopsies with 10 primary, untreated androgen-dependent tu ...[more]